| Alias | SARS-CoV-2/COVID-19 Omicron protein, SARS-CoV-2 Spike RBD Protein, recombinant 2019-nCoV S Omicron/B.1.1.529 protein |
| Catalog Number | COV444 |
| Molecular Name | SARS-CoV-2 (B.1.1.529/Omicron) |
| Species | COVID-19 |
| Host | HEK293 Cells |
| Size | 100ug |
| Purity | >95%, determined by SDS-PAGE |
| Purification | Affinity purification |
| Endotoxin | Less than 1.0 EU per ug by the LAL method. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. |
| Background | A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) emerged and is rapidly spreading in humans, causing COVID-19. A key to tackling this pandemic is to understand the receptor recognition mechanism of the virus, which regulates its infectivity, pathogenesis and host range. SARS-CoV-2 and SARS-CoV recognize the same receptor—angiotensin-converting enzyme 2 (ACE2)—in humans. Researchers determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2. In comparison with the SARS-CoV RBD, an ACE2-binding ridge in SARS-CoV-2 RBD has a more compact conformation, moreover, several residue changes in the SARS-CoV-2 RBD stabilize two virus-binding hotspots at the RBD–ACE2 interface. These structural features of SARS-CoV-2 RBD increase its ACE2-binding affinity. Additionally, we show that RaTG13, a bat coronavirus that is closely related to SARS-CoV-2, also uses human ACE2 as its receptor. |
| Predicted N Terminus | Arg 319 |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
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