Recombinant Mouse Kallikrein 7/Klk7 Protein, C-His tag
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产品编号
MOP2213
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别名
卡利克雷蛋白7, SCCE, Prss6, kallikrein related peptidase 7(chymotryptic, stratum corneum)
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | MOP2213 |
| Alias | 卡利克雷蛋白7, SCCE, Prss6, kallikrein related peptidase 7(chymotryptic, stratum corneum) |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | MOP2213 Recombinant Mouse Kallikrein 7/Klk7 Protein, C-His tag contains the mouse Klk7(Gln22-Arg249) was expressed in Mammalian cells. |
| Molecular Name | Klk7 |
| Product Introduction | Klk7 (MOP2213) 是丝氨酸蛋白酶，在皮肤的角质形成和脱屑中起作用。 |
| Molecular Weight | 27-37 kDa |
| Expression System | HEK293F Cells |
| Species | Mouse |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE | |
| Purification | Affinity Purification |
| Uniprot ID | Q91VE3 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Kallikrein-7 (KLK7) is also known as kallikrein-related peptidase 7, Stratum corneum chymotryptic enzyme, Serine protease 6, KLK7, and PRSS6, is a secreted protein which belongs to the peptidase S1 family and Kallikrein subfamily. KLK7 is secreted as an inactive zymogen in the stratum granulosum layer of the epidermis, requiring proteolytic cleavage of the short N-terminal pro-region to liberate activated enzyme. This may be performed by KLK5 or matriptase, which are in vitro activators of KLK7. Once active, KLK7 is able to cleave desmocollin and corneodesmosin. KLK7 activity is regulated by a number of endogenous protein inhibitors including LEKTI, SPINK6, elafin and alpha-2-Macroglobulin-like 1. Both Zn2+ and Cu2+ ions are also able to inhibit KLK7. Dysregulation of KLK7 has been linked to several skin disorders, and overexpression of KLK7 may provide a route for metastasis in several cancers. |
| Endotoxin | < 0.1 EU per ug |
| Protein Family | Other protein |
| Biological Activity | Measured by its ability to cleave the fluorogenic peptide substrate, McaRPKPVE-NvalWRK(Dnp)- NH2. The specific activity is >70 pmol/min/μg, as measured underthe described conditions. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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