Recombinant Human TGF-β3 Protein
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产品编号
KRP697
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别名
重组人TGF-β3蛋白,Transforming growth factor beta-3 proprotein, TGFB3
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规格
- 100ug
- 500ug
- 1mg
产品介绍
| Alias | 重组人TGF-β3蛋白,Transforming growth factor beta-3 proprotein, TGFB3 |
| Catalog Number | KRP697 |
| Molecular Name | TGF-β3 |
| Species | Human |
| Host | Sf9 Cells |
| Size | 100ug,500ug,1mg |
| Purity | >95%, determined by SDS-PAGE. |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purification | Affinity Purification |
| Endotoxin | <0.1 EU/μg, determined by LAL method. |
| Background | TGF-β家族的另一成员，与TGF-β1功能相似但也有其特异性。研究表明它在胚胎发育（特别是腭板融合）、伤口愈合（可能减少瘢痕）和免疫调节中发挥重要作用。 |
| Application | WB, ELISA |
| Predicted Molecular Weight | 12.7 kDa |
| Reconstitution | It is recommended that the lyophilized human TGF-β3 protein be dissolved in 4 mM HCl at a concentration of 50-200 μg/ml for further dilution as the working concentration. |
| Storage Condition | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Stability | Repeated freezing and thawing is not recommended. |
| Molecular Weight | 12 kDa |
| Uniprot ID | P10600 |
| References | 1. Barrio, M.C. et al. (2014) Cells Tissues Organs. [Epub ahead of print; PMID 24861080]. 2. Doetschman, T. et al. (2012) Genesis 50:59. 3. Mittl, P.R. et al. (1996) Protein Sci. 5:1261. 4. Sporn, M.B. (2006) Cytokine Growth Factor Rev. 17:3. 5. Wahl, S.M. et al. (2006) Immunol. Rev. 213:213. 6. Chang, H. et al. (2002) Endocr. Rev. 23:787. 7. Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem. 267:6982. 8. Jin, J.Z. et al. (2014) Dev. Dyn. [Epub ahead of print; PMID 25104574]. 9. Tang, Q.O. et al. (2009) Expert Opin. Biol Ther. 9:689. 10. Derynck, R. et al. (1988) EMBO J. 7:3737. 11. Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407. 12. Oklu, R. and R. Hesketh (2000) Biochem. J. 352 Pt 3:601. 13. Cui, X.M. and C.F. Shuler (2000) Int. J. Dev. Biol. 44:397. 14. de Caestecker, M. (2004) Cytokine Growth Factor Rev. 15:1. 15. Nakajima, A. et al. (2007) Dev. Dyn. 236:791. 16. Iwata, J. et al. (2012) J. Clin. Invest. 122:873. 17. Gatza, C.E. et al. (2010) Cell. Signal. 22:1163 |
| Function | 重组人转化生长因子-β3，是参与组织修复和胚胎发育的关键调节因子适用于瘢痕修复研究、胚胎发育模型及软骨组织工程。 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Temperature Range | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -41℃. Avoid repeated freeze-thaw cycles. |
| Product Full Name | Recombinant Human TGF-β3 Protein |
| Target | TGF-β3 |
FAQ
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TGF-β的功能特点是什么？
具有多重、环境依赖性的功能，包括抑制细胞增殖、调节免疫、以及强力诱导细胞外基质产生和间充质分化。
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在干细胞培养中最经典的应用是什么？
低浓度的TGF-β1/β3是诱导间充质干细胞向软骨细胞分化的金标准核心因子。此外，也用于诱导多能干细胞分化为间充质干细胞或调节性T细胞。
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