Recombinant Human TNF-alpha Protein, His Tag
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产品编号
KRP685
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别名
重组人TNF-α蛋白，TNFA, TNFSF2, TNF, Tumor necrosis factor
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规格
- 100ug
- 500ug
- 1mg
产品介绍
| Catalog Number | KRP685 |
| Alias | 重组人TNF-α蛋白，TNFA, TNFSF2, TNF, Tumor necrosis factor |
| Size | 100ug,500ug,1mg |
| Product Full Name | Recombinant Human TNF-a Protein |
| Molecular Name | TNF |
| Product Introduction | 重组人肿瘤坏死因子-α，是介导炎症反应和细胞凋亡的核心细胞因子。广泛应用于炎症信号通路研究、肿瘤细胞毒性实验及自身免疫疾病模型。 |
| Molecular Weight | 17 kDa |
| Target | TNF-a |
| Expression System | E.coli |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | >97%, determined by SDS-PAGE. |
| Purification | Affinity Purification |
| Uniprot ID | P01375 |
| Storage Condition | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
| Temperature Range | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -29℃. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | 一种主要由巨噬细胞和T细胞产生的核心促炎细胞因子，在全身性炎症、免疫调节、细胞存活/死亡中发挥核心作用，是类风湿关节炎、银屑病等自身免疫病的重要治疗靶点。 |
| Endotoxin | <0.01 EU/μg, determined by LAL method. |
| Predicted Molecular Weight | 17 kDa |
| Application | WB, ELISA |
| Reconstitution | It is recommended that the lyophilized human TNF-a protein be dissolved in sterile deionized water at a concentration of 0.1-1 mg/mL for further dilution as the working concentration. |
| Stability | Repeated freezing and thawing is not recommended. |
| References | 1. Zelova, H. and J. Hosek (2013) Inflamm. Res. 62:641. 2. Juhasz, K. et al. (2013) Expert Rev. Clin. Immunol. 9:335. 3. Pennica, D. et al. (1984) Nature 312:724. 4. Tang, P. et al. (1996) Biochemistry 35:8216. 5. Perez, C. et al. (1990) Cell 63:251. 6. Black, R.A. et al. (1997) Nature 385:729. 7. Moss, M.L. et al. (1997) Nature 385:733. 8. Gearing, A.J.H. et al. (1994) Nature 370:555. 9. Schall, T.J. et al. (1990) Cell 61:361. 10. Loetscher, H. et al. (1990) Cell 61:351. 11. Dembic, Z. et al. (1990) Cytokine 2:231. 12. Smith, C.A. et al. (1990) Science 248:1019. 13. Loetscher, H. et al. (1991) J. Biol. Chem. 266:18324. 14. Pinckard, J.K. et al. (1997) J. Biol. Chem. 272:10784. 15. Engelmann, H. et al. (1990) J. Biol. Chem. 265:1531. |
| Function | 重组人肿瘤坏死因子-α，是介导炎症反应和细胞凋亡的核心细胞因子。广泛应用于炎症信号通路研究、肿瘤细胞毒性实验及自身免疫疾病模型。 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
FAQ
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TNF-α是什么性质的因子？它是一种关键的促炎细胞因子，在急性炎症、免疫调节和诱导细胞凋亡中发挥核心作用。
它如何用于调控干细胞？通常不作为生长因子，而是作为条件信号。常用于“炎症预处理”间充质干细胞，以增强其免疫抑制功能和趋化能力；也用于模拟疾病炎症微环境。
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