Recombinant Human IL-6 Protein
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产品编号
KRP674
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别名
白细胞介素-6,Interleukin-6,BSF2,HSF,IFNB2
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规格
- 100ug
- 500ug
- 1mg
| Catalog Number | KRP674 |
| Alias | 白细胞介素-6,Interleukin-6,BSF2,HSF,IFNB2 |
| Size | 100ug,500ug,1mg |
| Product Full Name | Recombinant Human IL-6 Protein |
| Product Description | |
| Molecular Name | IL6 |
| Product Introduction | 重组人IL-6蛋白是采用大肠杆菌表达系统生产的高纯度细胞因子,其氨基酸序列与生物活性与人体天然白介素-6高度一致。本品具备超高比活性(ED₅₀ < 1 ng/mL)与卓越纯度(>95%),内毒素含量极低,确保了实验结果的可靠性与可重复性。作为免疫与炎症反应中的核心信使分子,它是研究免疫调节、造血发育、肿瘤微环境及自身免疫性疾病的关键工具。广泛应用于体外细胞培养扩增、信号通路机制探索以及药物筛选与开发,是推动生命科学基础研究与转化医学发展的理想核心试剂。 |
| Molecular Weight | 20-21 kDa |
| Target | IL6 |
| Expression System | E.coli |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | >97%, determined by SDS-PAGE. |
| Purification | Affinity Purification |
| Uniprot ID | P05231 |
| Storage Condition | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
| Temperature Range | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | 白介素6(IL-6)是一种关键的细胞因子,在免疫防御、急性炎症和造血中发挥重要作用。针对IL-6或其受体的抗体药物已成为治疗类风湿关节炎、细胞因子风暴等疾病的重要靶向疗法。 |
| Endotoxin | <0.1 EU/μg, determined by LAL method. |
| Predicted Molecular Weight | 20.9 kDa |
| Application | WB, ELISA |
| Reconstitution | It is recommended that the lyophilized human IL-6 protein be dissolved in PBS at a concentration of 100-200 μg/ml for further dilution as the working concentration. |
| Stability | Repeated freezing and thawing is not recommended. |
| References | 1. Mansell, A. and B.J. Jenkins (2013) Cytokine Growth Factor Rev. 24:249.. Schuett, H. et al. (2009) Thromb. Haemost. 102:215.. Erta, M. et al. (2012) Int. J. Biol. Sci. 8:1254.. Garbers, C. et al. (2012) Cytokine Growth Factor Rev. 23:85.. Mihara, M. et al. (2012) Clin. Sci. (Lond.) 122:143.. Hirano, T. et al. (1986) Nature 324:73.. Kestler, D.P. et al. (1995) Blood 86:4559.. Kestler, D.P. et al. (1999) Am. J. Hematol. 61:169.. Bihl, M.P. et al. (2002) Am. J. Respir. Cell Mol. Biol. 27:48.0. Alberti, L. et al. (2005) Cancer Res. 65:2.1. Murakami, M. et al. (1993) Science 260:1808.2. Muller-Newen, G. (2003) Sci. STKE 2003:PE40.3. Mitsuyama, K. et al. (2006) Clin. Exp. Immunol. 143:125.4. Cerutti, A. et al. (1998) J. Immunol. 160:2145. |
| Function | 研究免疫调节、造血发育、肿瘤微环境及自身免疫性疾病的关键工具,广泛应用于体外细胞培养扩增、信号通路机制探索以及药物筛选与开发,是推动生命科学基础研究与转化医学发展的理想核心试剂。 |
| Product Declaration | 该产品仅供科研使用,不可直接用于人体或注射。 |
蛋白可以在-80°C下储存以便长期保存。应分装并避免冻融循环,以保持蛋白的稳定性。
是的。IL-6具有促增殖/促分化与促炎症/促衰老的双重作用,需根据实验目的控制浓度与作用时间。长期高浓度IL-6可能引起干细胞耗竭或异常分化。
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