重组人头蛋白/Noggin/NOG蛋白，C-His标签|Recombinant Human Noggin Protein, C-His Tag

KRP407

Noggin,NOG,SYM1,SYNS1,SYNS1A

DATASHEET MSDS

产品介绍

Catalog Number	KRP407
Alias	Noggin,NOG,SYM1,SYNS1,SYNS1A
Size	20ug, 50ug, 100ug, 200ug, 1mg
Product Description	Human NOG(28-232 aa)
Molecular Name	NOG
Product Introduction	Noggin参与神经发育和修复的重要因子，促进神经再生。
Molecular Weight	35-38 kDa
Expression System	HEK293F Cells
Species	Human
Concentration	联系销售经理获得最新批次的浓度
Purity	≥95%
Purification	Affinity Purification
Uniprot ID	Q13253
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Formulation	Supplied in PBS
Shipping Condition	This product is shipped on ice packs or dry ice.
Background	Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732). {ECO:0000269\|PubMed:12478285, ECO:0000269\|PubMed:21976273, ECO:0000269\|PubMed:26643732}.
Endotoxin	< 0.1 EU per ug
Biological Activity	Immobilized Human BMP2 at 1 μg/mL (100 μL/well) can bind Noggin with a linearrange of 2- 57 ng/mL.
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何避免重组蛋白降解？

可在纯化过程中加入蛋白酶抑制剂、低温操作，优化储存条件（如分装冻存于-80°C），并避免反复冻融。某些情况下，可选用蛋白酶缺陷型宿主菌减少降解风险。
如何检测重组蛋白的表达和纯度？

常用SDS-PAGE、Western Blot检测表达，BCA/Bradford法测浓度，HPLC或质谱分析纯度，生物活性实验（如ELISA、酶活检测）验证功能。

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