重组小鼠头蛋白/Noggin/NOG蛋白,C-10*His标签|Recombinant Mouse Noggin Protein, C-10*His tag
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产品编号
KRP364
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别名
Noggin,NOG,SYM1,SYNS1,SYNS1A
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
| Catalog Number | KRP364 |
| Alias | Noggin,NOG,SYM1,SYNS1,SYNS1A |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Mouse Nog(20-232 aa) |
| Molecular Name | NOG |
| Product Introduction | Noggin在神经发育和修复过程中发挥重要作用。 |
| Molecular Weight | 30-35 kDa |
| Expression System | HEK293F Cells |
| Species | Mouse |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥90% |
| Purification | Affinity Purification |
| Uniprot ID | P97466 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | Supplied in PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (PubMed:9585504, PubMed:9603738). Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (By similarity). {ECO:0000250|UniProtKB:Q13253, ECO:0000269|PubMed:9585504, ECO:0000269|PubMed:9603738}. |
| Endotoxin | < 0.1 EU per ug |
| Biological Activity | Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 forthis effect is 0.06-0.3 µg/mL in the presence of 50 ng/mL of Recombinant Human BMP-4. |
| Product Declaration | 该产品仅供科研使用,不可直接用于人体或注射。 |
蛋白可以在-80°C下储存以便长期保存。应分装并避免冻融循环,以保持蛋白的稳定性。
可以通过优化质粒设计、使用高效转染试剂、优化细胞培养条件以及使用蛋白折叠伴侣或密码子优化来提高蛋白表达效率。
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