KMP4953
Stress-activated protein kinase kinase 2 (SAPK kinase 2;SAPKK-2;SAPKK2), SKK2, PRKMK3, MKK3, MEK3, MAPKK 3, MAPK/ERK kinase 3 (MEK 3), MAP2K3, MAP kinase kinase 3, Dual specificity mitogen-activated protein kinase kinase 3
| Alias | Stress-activated protein kinase kinase 2 (SAPK kinase 2;SAPKK-2;SAPKK2), SKK2, PRKMK3, MKK3, MEK3, MAPKK 3, MAPK/ERK kinase 3 (MEK 3), MAP2K3, MAP kinase kinase 3, Dual specificity mitogen-activated protein kinase kinase 3 |
| Catalog Number | KMP4953 |
| Product Description | MAP2K3蛋白是一种双特异性蛋白激酶，属于 MAP 激酶激酶家族 ，该激酶被有丝分裂和环境应激激活，参与MAP激酶介导的信号级联反应。它磷酸化并激活MAPK14/p38-MAPK。该激酶可被胰岛素激活，是葡萄糖转运蛋白表达的必要条件。表达Ras致癌基因会导致该激酶活性形式的积累，从而促进MAPK14的本质性激活，并赋予原级细胞的致癌转化。该激酶的抑制参与了叶尔西纳假性病的发病机制。 |
| Molecular Name | MAP2K3 |
| Species | Human |
| Host | E.coli |
| Size | 20ug,100ug,1mg |
| Protein Family | MAP激酶家族 |
| Purity | ≥95% |
| Purification | Affinity purification |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from 20 mM HEPES, 150 mM NaCl, pH 7.4 |
| Background | MAP2K3蛋白是一种双特异性蛋白激酶，属于 MAP 激酶激酶家族 ，该激酶被有丝分裂和环境应激激活，参与MAP激酶介导的信号级联反应。它磷酸化并激活MAPK14/p38-MAPK。该激酶可被胰岛素激活，是葡萄糖转运蛋白表达的必要条件。表达Ras致癌基因会导致该激酶活性形式的积累，从而促进MAPK14的本质性激活，并赋予原级细胞的致癌转化。该激酶的抑制参与了叶尔西纳假性病的发病机制。 |
| Tag | N-His，C-Avi |
| Biological Activity | Not Test |
| Predicted Molecular Weight | 48.6kDa |
| Reconstitution | Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL |
| Storage Condition | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | 干冰运输 |
| Stability | 不建议反复冻融 |
| Sequence | 1-347AA |
| Molecular Weight | 48.6kDa |
| Uniprot ID | P46734 |
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