Mouse CLEC3A Protein, His Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Mouse CLEC3A Protein, His Tag

Mouse CLEC3A Protein, His Tag

产品编号

KMP3951

别名

C型凝集素域家族3成员A, CLEC3A Protein, Mouse CLEC3A Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	C型凝集素域家族3成员A, CLEC3A Protein, Mouse CLEC3A Protein, His Tag
Catalog Number	KMP3951
Product Description	The Mouse CLEC3A Protein(KMP3951) is produced in Insect Cells. A DNA sequence encoding the Mouse CLEC3A (NP_001007224.1) (Met1-Pro196) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	CLEC3A
Species	Mouse
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 300mM NaCl, 10% Glycerol, pH8.0
Background	C-type lectin domain family 3 member A (CLEC3A) is a poorly characterized protein belonging to the superfamily of C-type lectins. Elevated CLEC3A expression may correlate with breast IDC metastatic potential and indicated a poor prognosis in breast IDC. CLEC3A knockdown inhibited BC cell growth and metastasis might be through suppressing PI3K/AKT signaling activity. That CLEC3A is a promising therapeutic target for BC in the future. Matrilysin (MMP-7) plays important roles in tumor progression. Previous studies have suggested that MMP-7 binds to tumor cell surface and promotes their metastatic potential. C-type lectin domain family 3 member A (CLEC3A) as a membrane-bound substrate of MMP-7. CLEC3A binds to heparan sulfate proteoglycans on cell surface, leading to the enhancement of cell adhesion to integrin ligands on ECM. It can be speculated that the cleavage of CLEC3A by MMP-7 weakens the stable adhesion of tumor cells to the matrix and promotes their migration in tumor microenvironments.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	21.3 kDa

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0