Mouse MBL2 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Mouse MBL2 Protein, mFc Tag

Mouse MBL2 Protein, mFc Tag

产品编号

KMP3830

别名

甘露糖结合凝集素2, MBL2 Protein, Mouse MBL2 Protein, mFc Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	甘露糖结合凝集素2, MBL2 Protein, Mouse MBL2 Protein, mFc Tag
Catalog Number	KMP3830
Product Description	The Mouse MBL2 Protein(KMP3830) is produced in HEK293 Cells. A DNA sequence encoding the Mouse Mbl2 (NP_034906.1) (Glu19-Asp244) is expressed with the Fc region of Mouse IgG1 at the N-terminus.
Molecular Name	MBL2
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein, which binds sugar structures on micro-organisms and dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. MBL and the ficolins (Ficolin-1, Ficolin-2, and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune defense. They bind sugar structures or acetylated compounds present on microorganisms and dying host cells and they initiate activation of the lectin complement pathway in varying degrees. MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in the development of type 1 diabetes and gestational diabetes mellitus. Common variant alleles situated both in the promoter and structural regions of the MBL2 gene influence the stability and the serum concentration of the protein. Several polymorphisms in the promoter and structural regions of MBL2 adversely affect the plasma concentration and the oligomeric state of MBL. The possession of mutant alleles has been linked to disease outcomes for a variety of bacterial and viral infections. Mutant MBL2 haplotypes have been linked to disease progression and response to therapy in HCV infection.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	50.6 kDa

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