Human ITK Protein, GST Tag_天津卡梅德科技发展有限公司

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Human ITK Protein, GST Tag

Human ITK Protein, GST Tag

产品编号

KMP3553

别名

IL2 诱导型 T 细胞激酶, Human ITK Protein, GST Tag, ITK

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	IL2 诱导型 T 细胞激酶, Human ITK Protein, GST Tag, ITK
Catalog Number	KMP3553
Product Description	The Human ITK Protein(KMP3553) is produced in Insect Cells. The target gene encoding the human ITK (NP_005537.3) (Arg352-Leu620) is expressed with a GST tag at the N-terminus. The purified ITK is actived by LCK.
Molecular Name	ITK
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>75% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	50mM Tris, 150mM NaCl, 25% Glycerol, 0.5mM PMSF, 0.5mM TCEP, 0.1mM EDTA, 0.5mM GSH, pH7.5
Background	IL-2-inducible T cell kinase is a member of the protein kinase superfamily, Tyr protein kinase family, and TEC subfamily. It contains 1 Btk-type zinc finger, 1 PH domain, 1 protein kinase domain, 1 SH2 domain, and 1 SH3 domain. As an intracellular kinase expressed in T-cells, IL-2-inducible T cell kinase contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. It regulates the development, function, and differentiation of conventional T-cells and nonconventional NKT-cells. IL-2-inducible T cell kinase also plays an essential role in the regulation of the adaptive immune response. Effects in IL-2-inducible T cell kinase are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1). LPSA1 is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Inadequate immune response to EBV can have a fatal outcome. Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk of lymphoma.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	57.7 kDa

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