Human SIRT5 Protein, Flag Tag_天津卡梅德科技发展有限公司

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Human SIRT5 Protein, Flag Tag

Human SIRT5 Protein, Flag Tag

产品编号

KMP3439

别名

NAD依赖性蛋白脱酰酶Sirtuin-5, Human SIRT5 Protein, Flag Tag, SIRT5

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	NAD依赖性蛋白脱酰酶Sirtuin-5, Human SIRT5 Protein, Flag Tag, SIRT5
Catalog Number	KMP3439
Product Description	The Human SIRT5 Protein(KMP3439) is produced in E. coli. The target gene encoding the human SIRT5 (NP_036373.1) (Arg2-Ser310) is expressed with a FLAG tag at the N-terminus.
Molecular Name	SIRT5
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>75% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, 1mM DTT, pH8.2
Background	The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups SIRT5 as a significant regulator of cellular homeostasis, in a context- and cell-type specific manner, as has been observed previously for other sirtuin family members. SIRT5 regulates protein substrates involved in glycolysis, the TCA cycle, fatty acid oxidation, electron transport chain, ketone body formation, nitrogenous waste management, and ROS detoxification, among other processes. SIRT5 plays pivotal roles in cardiac physiology and stress responses and is involved in the regulation of numerous aspects of myocardial energy metabolism. SIRT5 is implicated in neoplasia, as both a tumor promoter and suppressor in a context-specific manner, and may serve a protective function in the setting of neurodegenerative disorders. The SIRT5 downregulation is associated with increased succinylation and activity of ACOX1 and oxidative DNA damage response in hepatocellular carcinoma (HCC).
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	34.9 kDa

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