Human RGMB Protein, His Tag
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产品编号
KMP3411
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别名
排斥性引导分子 BMP 辅助受体 b, Human RGMB Protein, His Tag, RGMB
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规格
- 50ug
- 100ug
- 200ug
Alias | 排斥性引导分子 BMP 辅助受体 b, Human RGMB Protein, His Tag, RGMB |
Catalog Number | KMP3411 |
Product Description | The Human RGMB Protein(KMP3411) is produced in HEK293 Cells. The target gene encoding the human RGMB (NP_001012779.2) (Met1-Asn413) is expressed with a polyhistidine tag at the C-terminus. |
Molecular Name | RGMB |
Species | Human |
Host | HEK293 Cells |
Size | 50ug, 100ug, 200ug |
Purity | >90% as determined by SDS-PAGE |
Purification | Affinity purification |
Endotoxin | <1.0 EU/ug determined by the LAL method |
Formulation | PBS, pH7.4 |
Background | RGMB was knocked down in breast cancer cells by way of an anti-RGMB ribozyme transgene. Knockdown of RGMB resulted in enhanced capacities of proliferation, adhesion, and migration in breast cancer cells. Further investigations demonstrated RGMB knockdown resulted in a reduced expression and activity of Caspase-3, accompanied with better survival in RGMB knockdown cells under serum starvation, which might be induced by its repression on MAPK JNK pathway. That RGMB may act as a negative regulator in breast cancer through BMP signaling. |
Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
Molecular Weight | 42 kDa |