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Human RGMB Protein, His Tag

Human RGMB Protein, His Tag

产品编号

KMP3411

别名

排斥性引导分子 BMP 辅助受体 b, Human RGMB Protein, His Tag, RGMB

规格
  • 50ug
  • 100ug
  • 200ug
产品介绍
Alias排斥性引导分子 BMP 辅助受体 b, Human RGMB Protein, His Tag, RGMB
Catalog NumberKMP3411
Product DescriptionThe Human RGMB Protein(KMP3411) is produced in HEK293 Cells. The target gene encoding the human RGMB (NP_001012779.2) (Met1-Asn413) is expressed with a polyhistidine tag at the C-terminus.
Molecular NameRGMB
SpeciesHuman
HostHEK293 Cells
Size50ug, 100ug, 200ug
Purity>90% as determined by SDS-PAGE
PurificationAffinity purification
Endotoxin<1.0 EU/ug determined by the LAL method
FormulationPBS, pH7.4
BackgroundRGMB was knocked down in breast cancer cells by way of an anti-RGMB ribozyme transgene. Knockdown of RGMB resulted in enhanced capacities of proliferation, adhesion, and migration in breast cancer cells. Further investigations demonstrated RGMB knockdown resulted in a reduced expression and activity of Caspase-3, accompanied with better survival in RGMB knockdown cells under serum starvation, which might be induced by its repression on MAPK JNK pathway. That RGMB may act as a negative regulator in breast cancer through BMP signaling.
Storage ConditionAliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping ConditionIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight42 kDa

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