Human FGFR3 Protein, His Tag_天津卡梅德科技发展有限公司

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Human FGFR3 Protein, His Tag

Human FGFR3 Protein, His Tag

产品编号

KMP3377

别名

成纤维细胞生长因子受体3, Human FGFR3 Protein, His Tag, FGFR3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	成纤维细胞生长因子受体3, Human FGFR3 Protein, His Tag, FGFR3
Catalog Number	KMP3377
Product Description	The Human FGFR3 Protein(KMP3377) is produced in HEK293 Cells. The target gene encoding the human FGFR3(alpha(IIIb)) (NP_001156685.1) (Met1-Gly377) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	FGFR3
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. FGFRs are transmembrane catalytic receptors that have intracellular tyrosine kinase activity. Mutations in FGFR genes are the cause of several human developmental disorders characterized by skeletal abnormalities such as achondroplasia, and upregulation of FGFR expression may lead to cell transformation and cancer. FGFR3, a full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR3 binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGFR3 gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. CD333 is the receptor for acidic and basic fibroblast growth factors.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	40 kDa

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