Human THRB Protein, His Tag_天津卡梅德科技发展有限公司

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Human THRB Protein, His Tag

Human THRB Protein, His Tag

产品编号

KMP3277

别名

重组人甲状腺激素受体β抗体, Human THRB Protein, His Tag, THRB

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	重组人甲状腺激素受体β抗体, Human THRB Protein, His Tag, THRB
Catalog Number	KMP3277
Product Description	The Human THRB Protein(KMP3277) is produced in E. coli. The target gene encoding the Human THRB (P10828-1) (Glu202-Asp461) is expressed, with a polyhistidine tag at the N-terminus.
Molecular Name	THRB
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	50mM Tris, 1mM Tcep, pH8.0
Background	Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone/ligand-binding domain, THRB isoform 1/2 expression localizes predominately to the liver and pituitary, respectively. THRB regulates the feedback of T3-dependent thyrotropin-stimulating hormone (TSH) transcription in the pituitary by binding to thyroid hormone (TH) response elements present on promoters of TH-responsive genes. Located on chromosome 3p24, THRB gene mutation has been linked to autosomal dominant resistance to TH (RTH), which is characterized by goiter and elevated levels of T3, T4, and TSH. THRB is a known pharmacological target for the treatment of non-alcoholic steatohepatitis (NASH). THRB may be a target for future cancer therapies since its knockdown enhanced the viability of endometrial cancer cells and activated the mTOR-4EBP1/eIF4G pathway.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	30.33 kDa

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