Human PKLR Protein, His Tag_天津卡梅德科技发展有限公司

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Human PKLR Protein, His Tag

Human PKLR Protein, His Tag

产品编号

KMP3236

别名

丙酮酸激酶 L/R, Human PKLR Protein, His Tag, PKLR

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	丙酮酸激酶 L/R, Human PKLR Protein, His Tag, PKLR
Catalog Number	KMP3236
Product Description	The Human PKLR Protein(KMP3236) is produced in E. coli. The target gene encoding the human PKLR (NP_000289.1) (Leu47-Ser574) is expressed with a polyhistidine tag at the N-terminus.
Molecular Name	PKLR
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pathway and the most common cause of hereditary nonspherocytic hemolytic anemia. Over 250 PKLR-gene mutations have been described, including missense/nonsense, splicing and regulatory mutations, small insertions, small and gross deletions, causing PKD and hemolytic anemia of variable severity. PKLR expression was increased in liver metastases as well as in primary colorectal tumors of patients with metastatic disease. PKLR protein variants may affect the frequency, and the intensity of malaria episodes induced by different Plasmodium parasites in humans living in areas of endemic malaria.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	59.1 kDa

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