Human ENSA Protein, His Tag_天津卡梅德科技发展有限公司

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Human ENSA Protein, His Tag

Human ENSA Protein, His Tag

产品编号

KMP3144

别名

内硫素α, Human ENSA Protein, His Tag, ENSA

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	内硫素α, Human ENSA Protein, His Tag, ENSA
Catalog Number	KMP3144
Product Description	The Human ENSA Protein(KMP3144) is produced in E. coli. The target gene encoding the mature form of human ENSA (O43768-1) (Met1-Glu121) is expressed with a polyHistide tag at the N-terminus. The purified protein is biotinylated in vitro.
Molecular Name	ENSA
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Endosulfine alpha, also known as ENSA, belongs to the endosulfine family. It is a highly conserved cAMP-regulated phosphoprotein (ARPP) family. Endosulfine alpha is widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. As a protein phosphatase inhibitor, ENSA specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase By similarity. Endosulfine alpha also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	15.2 kDa

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