Human Insulin Receptor Protein, His Tag_天津卡梅德科技发展有限公司

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Human Insulin Receptor Protein, His Tag

Human Insulin Receptor Protein, His Tag

产品编号

KMP2852

别名

胰岛素受体, Human Insulin Receptor Protein, His Tag, Insulin Receptor

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	胰岛素受体, Human Insulin Receptor Protein, His Tag, Insulin Receptor
Catalog Number	KMP2852
Product Description	The Human Insulin Receptor Protein(KMP2852) is produced in HEK293 Cells. The target gene encoding the human INSR isoform long (NP_000199.2) extracellular domain (Met1-Lys956) is expressed, fused with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro.
Molecular Name	Insulin Receptor
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	INSR (Insulin receptor), also known as CD22, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually lead to an increase in the high-affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen, and placenta. Defects in Insulin Receptor/INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism (Donohue syndrome), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM).
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	107 kDa

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