Human alanyl-tRNA synthetase Protein, His Tag_天津卡梅德科技发展有限公司

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Human alanyl-tRNA synthetase Protein, His Tag

Human alanyl-tRNA synthetase Protein, His Tag

产品编号

KMP2803

别名

丙氨酰-tRNA合成酶, Human alanyl-tRNA synthetase Protein, His Tag, alanyl-tRNA synthetase

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	丙氨酰-tRNA合成酶, Human alanyl-tRNA synthetase Protein, His Tag, alanyl-tRNA synthetase
Catalog Number	KMP2803
Product Description	The Human alanyl-tRNA synthetase Protein(KMP2803) is produced in Insect Cells. The target gene encoding the human AARS (NP_001596.2) (Met1-Asn968) is expressed with a polyhistidine tag at the N-terminus.
Molecular Name	alanyl-tRNA synthetase
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM PB, 500mM NaCl, 20% Glycerol, pH7.0
Background	Alanyl-tRNA synthetase (AARS) belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. This enzyme participates in alanine and aspartate metabolism and aminoacyl-tRNA biosynthesis. Alanyl-tRNA synthetase (AlaRS) catalyzes synthesis of Ala-tRNA (Ala) and hydrolysis of mis-acylated Ser- and Gly-tRNA (Ala) at 2 different catalytic sites. Their role is not confined to catalyze the attachment of amino acids to transfer RNAs and thereby establish the rules of genetic code by virtue of matching the nucleotide triplet of anticodon with cognate amino acid. Under apoptotic conditions in cell culture, the full-length enzyme is secreted, and the two cytokine activities can be generated by leukocyte elastase, an extracellular protease. Secretion of this tRNA synthetase may contribute to apoptosis both by arresting translation and producing needed cytokines. This protein could be an attractive target of drugs against bacterial, fungal and parasitic infections.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	109.2 kDa

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