Human NOTCH2 Protein, His Tag_天津卡梅德科技发展有限公司

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Human NOTCH2 Protein, His Tag

Human NOTCH2 Protein, His Tag

产品编号

KMP2798

别名

神经源性基因座notch同源蛋白-2, Human NOTCH2 Protein, His Tag, NOTCH2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	神经源性基因座notch同源蛋白-2, Human NOTCH2 Protein, His Tag, NOTCH2
Catalog Number	KMP2798
Product Description	The Human NOTCH2 Protein(KMP2798) is produced in Insect Cells. The target gene encoding the human NOTCH2 (NP_001186930.1) (Met1-Gln530) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	NOTCH2
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 500mM NaCl, 10% Glycerol, pH8.0
Background	NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of developmental processes by controlling cell fate decisions. Hajdu Cheney Syndrome (HCS) is a rare disease associated with mutations of NOTCH2 that lead to the translation of a truncated, presumably stable, NOTCH2 protein. NOTCH2 is down-regulated in colon cancer, and reduced expression is associated with a less differentiated, more aggressive phenotype, and reduced overall survival. NOTCH2 has also been shown to have pro-apoptotic and growth-suppressive effects in thyroid carcinoma, and carcinoid tumors. NOTCH2 acts as an oncogene that promotes bladder cancer growth and metastasis through EMT, cell-cycle progression, and maintenance of stemness.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	55.5 kDa

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