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Human EPOR Protein, His Tag

Human EPOR Protein, His Tag

产品编号

KMP2714

别名

钙黏蛋白E, Human EPOR Protein, His Tag, EPOR

规格
  • 50ug
  • 100ug
  • 200ug
产品介绍
Alias钙黏蛋白E, Human EPOR Protein, His Tag, EPOR
Catalog NumberKMP2714
Product DescriptionThe Human EPOR Protein(KMP2714) is produced in HEK293 Cells. The target gene encoding the extracellular domain (Met1-Pro250) of human EPOR (NP_000112.1) is fused with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro.
Molecular NameEPOR
SpeciesHuman
HostHEK293 Cells
Size50ug, 100ug, 200ug
Purity>95% as determined by SDS-PAGE
PurificationAffinity purification
Endotoxin<1.0 EU/ug determined by the LAL method
FormulationPBS, pH7.4
BackgroundErythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR/EPO Receptor) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR protein is a type â… single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR signaling prevents neuronal death and ischemic injury. Recent studies have shown that EPO and EPOR protein may be involved in carcinogenesis, angiogenesis, and invasion.
Storage ConditionAliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping ConditionIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight26.3 kDa

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