Human CCL28 Protein, His Tag_天津卡梅德科技发展有限公司

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Human CCL28 Protein, His Tag

Human CCL28 Protein, His Tag

产品编号

KMP2670

别名

CC 基序趋化因子配体 28, Human CCL28 Protein, His Tag, CCL28

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	CC 基序趋化因子配体 28, Human CCL28 Protein, His Tag, CCL28
Catalog Number	KMP2670
Product Description	The Human CCL28 Protein(KMP2670) is produced in E. coli. The target gene encoding the human CCL28 (NP_683513.1) (Ile23-Tyr127) is expressed with a polyhistidine tag at the N-terminus.
Molecular Name	CCL28
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CCL28 chemokine is expressed by epithelial cells of various mucosal tissues. This chemokine binds to CCR3 and CCR10 receptors and plays an essential role in the IgA antibody secreting cells (IgA-ASC) homing to mucosal surfaces and lactating mammary gland as well. Besides, CCL28 has been shown to exert a potent antimicrobial activity against both Gram-negative and Gram-positive bacteria and fungi. The potent antimicrobial function of CCL28 combined with its wide distribution in mucosal tissues and secretions suggest that this protein plays an important role in innate immune protection of the epithelial surfaces. CCL28 is a human chemokine constitutively expressed by epithelial cells in diverse mucosal tissues and is known to attract a variety of immune cell types including T-cell subsets and eosinophils. Elevated levels of CCL28 have been found in the airways of individuals with asthma, and previous studies have indicated that CCL28 plays a vital role in the acute development of post-viral asthma. CCL28 presents a novel target for the development of alternative asthma therapeutics. The dental decay of children leads to the secretion of chemokine CCL28, which promotes the secretion of sIgA in saliva. CC chemokine ligand28 (CCL28) has been reported as a severity marker in atopic dermatitis.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	14.2 kDa

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