Human Bcl2A1 Protein, His Tag_天津卡梅德科技发展有限公司

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Human Bcl2A1 Protein, His Tag

Human Bcl2A1 Protein, His Tag

产品编号

KMP2650

别名

细胞白血病/淋巴瘤2 相关蛋白, Human Bcl2A1 Protein, His Tag, Bcl2A1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	细胞白血病/淋巴瘤2 相关蛋白, Human Bcl2A1 Protein, His Tag, Bcl2A1
Catalog Number	KMP2650
Product Description	The Human Bcl2A1 Protein(KMP2650) is produced in E. coli. The target gene encoding the human BCL2A1 (NP_004040 ) (Met1-Ser152) is expressed with a polyhistidine tag at the N-terminus.
Molecular Name	Bcl2A1
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs. Immunohistochemical expression of Wnt11 and BCL2A1 in complete moles and normal villi. Bcl2 family proteins control mitochondrial apoptosis and its members exert critical cell type and differentiation stage-specific functions, acting as barriers against autoimmunity or transformation. Anti-apoptotic Bcl2a1/Bfl1/A1 is frequently deregulated in different types of blood cancers in humans but its physiological role is poorly understood as quadruplication of the Bcl2a1 gene locus in mice hampers conventional gene targeting strategies. In a physiological context, BCL2A1 is mainly expressed in the hematopoietic system, where it facilitates survival of selected leukocytes subsets and inflammation. However, BCL2A1 is overexpressed in a variety of cancer cells, including hematological malignancies and solid tumors, and may contribute to tumor progression. The development of small molecule inhibitors of BCL2A1 may be a promising approach mainly to sensitize tumor cells for apoptosis and thus improve the efficiency of anti-cancer therapy.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	19.7 kDa

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