Human CCN4 Protein, His Tag_天津卡梅德科技发展有限公司

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Human CCN4 Protein, His Tag

Human CCN4 Protein, His Tag

产品编号

KMP2606

别名

富半胱复酸蛋白61, Human CCN4 Protein, His Tag, CCN4

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	富半胱复酸蛋白61, Human CCN4 Protein, His Tag, CCN4
Catalog Number	KMP2606
Product Description	The Human CCN4 Protein(KMP2606) is produced in HEK293 Cells. The target gene encoding the human WISP1 (NP_003873.1) (Met 1-Asn 367) is expressed with a C-terminal polyhistidine tag.
Molecular Name	CCN4
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>80% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CCN4/Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF/CYR61/NOV) family of growth factors, and is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, tissue repair, and regulation of extracellular matrix. Members of the CCN family demonstrate high structural homology sharing four conserved cysteine-rich modular domains: an IGFBP (insulin-like growth factor-binding) domain, a von Willebrand type C domain, a thrombospondin domain and a C-terminal cysteine -knot domain. WISP1 is a putative downstream effector of the Wnt/Frizzled pathway that mediates diverse developmental processes, was identified as an oncogene regulated by the Wnt-1-beta-catenin pathway. Thus WISP1 may contribute to Wnt-1-mediated tumorigenesis and malignance. Expression of WISP1 in some cells results in transformation and tumorigenesis. WISP1 acts to block cell death at a late stage in the p53-mediated apoptosis pathway. It was reported that WISP1 interacts with sulfated glycoconjugates, decorin and biglycan in the ECM of connective tissue, and possibly prevents their inhibitory activity in tumor cell proliferation.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	39 kDa

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