Human TGFBR2 Protein, His Tag_天津卡梅德科技发展有限公司

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Human TGFBR2 Protein, His Tag

Human TGFBR2 Protein, His Tag

产品编号

KMP2574

别名

转化生长因子 β 受体 2, Human TGFBR2 Protein, His Tag, TGFBR2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	转化生长因子 β 受体 2, Human TGFBR2 Protein, His Tag, TGFBR2
Catalog Number	KMP2574
Product Description	The Human TGFBR2 Protein(KMP2574) is produced in Insect Cells. The target gene encoding the human TGFBR2 (NP_003233.4) (Met1-Gln166) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	TGFBR2
Species	Human
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM PBS, 150mM NaCl, 10% Glycerol, 0.5mM TCEP, pH7.0
Background	TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilized by a network of six intra strand disulfide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets. TGFBR2 has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is increased in oral squamous cell carcinoma cells. Its expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	17.8 kDa

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