Human SPINT2 Protein, His Tag_天津卡梅德科技发展有限公司

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Human SPINT2 Protein, His Tag

Human SPINT2 Protein, His Tag

产品编号

KMP2554

别名

丝氨酸肽酶抑制因子, Kunitz 2 型, Human SPINT2 Protein, His Tag, SPINT2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	丝氨酸肽酶抑制因子, Kunitz 2 型, Human SPINT2 Protein, His Tag, SPINT2
Catalog Number	KMP2554
Product Description	The Human SPINT2 Protein(KMP2554) is produced in HEK293 Cells. The target gene encoding the human SPINT2 (NP_066925.1) (Met1-Lys197) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	SPINT2
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Choanal (CA) and gastrointestinal atresias (GA) are an important feature of syndromic congenital sodium diarrhea (sCSD), a disorder recently associated with mutations in the gene for serine protease inhibitor type 2 (SPINT2). The SPINT2 gene is epigenetically silenced or downregulated in human cancers, altering the balance of HGF activation/inhibition ratio, which contributes to cancer development and progression. SPINT2 is a tumor suppressor gene that inhibits proteases implicated in cancer progression, like HGFA, hepsin and matriptase. Loss of SPINT2 expression in tumors has been associated with gene promoter hypermethylation. SPINT2 (serine peptidase inhibitor Kunitz type 2), a proteolytic inhibitor of hepatocyte growth factor activator (HGFA), has a significant role in the suppression of the HGF-MET pathway and malignant melanoma progression.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	20.6 kDa

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