Human Nucleophosmin Protein, His Tag_天津卡梅德科技发展有限公司

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Human Nucleophosmin Protein, His Tag

Human Nucleophosmin Protein, His Tag

产品编号

KMP2468

别名

核磷蛋白 1, Human Nucleophosmin Protein, His Tag, Nucleophosmin

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	核磷蛋白 1, Human Nucleophosmin Protein, His Tag, Nucleophosmin
Catalog Number	KMP2468
Product Description	The Human Nucleophosmin Protein(KMP2468) is produced in E. coli. The target gene encoding the human NPM1 isoform 1 (P06748-1) (Glu2-Leu294) is expressed with a polyHistide tag at the N-terminus.
Molecular Name	Nucleophosmin
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	30mM HEPES, 2mM EDTA, 0.001% Tween, 15% Glycerol, pH7.0
Background	Nucleophosmin 1 (NPM1), also known as nucleolar phosphoprotein B23 or numatrin, is a member of the nucleoplasmin family. Nucleophosmin (NPM) is a nucleolar phosphoprotein that plays multiple roles in ribosome assembly and transport, cytoplasmic-nuclear trafficking, centrosome duplication, and regulation of p53. The NPM1 gene is frequently involved in chromosomal translocation, mutation, and deletion. Mutations of the NPM1 gene leading to the expression of a cytoplasmic mutant protein, NPMc+, are the most frequent genetic abnormalities found in acute myeloid leukemias. Acute myeloid leukemia (AML) with mutated NPM1 have distinct characteristics, including a significant association with a normal karyotype, the involvement of different hematopoietic lineages, a specific gene-expression profile, and clinically, a better response to induction therapy, and a favorable prognosis. Also, NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer. NPM1 is frequently overexpressed, mutated, rearranged, and deleted in human cancer. Traditionally regarded as a tumor marker and a putative proto-oncogene, it has now also been attributed with tumor-suppressor functions.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	34 kDa

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