Human CD166 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human CD166 Protein, hFc Tag

Human CD166 Protein, hFc Tag

产品编号

KMP2467

别名

活化的白细胞粘附分子, Human CD166 Protein, hFc Tag, CD166

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	活化的白细胞粘附分子, Human CD166 Protein, hFc Tag, CD166
Catalog Number	KMP2467
Product Description	The Human CD166 Protein(KMP2467) is produced in HEK293 Cells. The target gene encoding the human ALCAM (NP_001618.2) (Met1-Ala526) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	CD166
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Activated leukocyte cell adhesion molecule (ALCAM)/Cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocytes. The extracellular domain of ALCAM contains five Ig-like domains (three Ig-like C2-type domains and two Ig-like V-type domains), of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation. ALCAM mediates both heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- and B-cells to activated leukocytes. Recently, homophilic (ALCAM-ALCAM) adhesion was shown to play important roles in tight cell-to-cell interaction and regulation of stem cell differentiation. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration, including neural development, branching organ development, hematopoiesis, immune response and tumor progression. And CD166 is regarded as a potential novel breast cancer indicator and therapeutic target.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	82.7 kDa

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