Human CD357 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human CD357 Protein, mFc Tag

Human CD357 Protein, mFc Tag

产品编号

KMP2434

别名

肿瘤坏死因子受体超家族成员 18, Tumor necrosis factor receptor superfamily member 18, CD357

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2434
Alias	肿瘤坏死因子受体超家族成员 18, Tumor necrosis factor receptor superfamily member 18, CD357
Size	50ug, 100ug, 200ug
Product Description	The Human CD357 Protein(KMP2434) is produced in HEK293 Cells and the target gene encoding Gln26-Glu161(Thr45Ala) is expressed with a mFc tag at the C-terminus.
Molecular Name	CD357
Product Introduction	CD357（TNFRSF18）：一种TNF受体超家族跨膜蛋白，主要表达于T细胞表面，通过配体结合参与免疫细胞活化和功能调控。
Molecular Weight	14.53 kDa
Expression System	HEK293 Cells
Species	Human
Purity	>90%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	Q9UNG2
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何储存293F细胞中表达的蛋白？

蛋白可以在-80°C下储存以便长期保存。应分装并避免冻融循环，以保持蛋白的稳定性。
如何提高293F细胞中的蛋白表达效率？

可以通过优化质粒设计、使用高效转染试剂、优化细胞培养条件以及使用蛋白折叠伴侣或密码子优化来提高蛋白表达效率。

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