Rhesus Macaque CD357 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Rhesus Macaque CD357 Protein, mFc Tag

Rhesus Macaque CD357 Protein, mFc Tag

产品编号

KMP2433

别名

肿瘤坏死因子受体超家族成员 18, Tumor necrosis factor receptor superfamily member 18, CD357

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2433
Alias	肿瘤坏死因子受体超家族成员 18, Tumor necrosis factor receptor superfamily member 18, CD357
Size	50ug, 100ug, 200ug
Product Description	The Rhesus Macaque CD357 Protein(KMP2433) is produced in HEK293 Cells and the target gene encoding Met1-Asn343 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD357
Product Introduction	CD357（TNFRSF18）：一种TNF受体超家族跨膜蛋白，主要表达于T细胞表面，通过配体结合参与免疫细胞活化和功能调控。
Molecular Weight	38.39 kDa
Expression System	HEK293 Cells
Species	Rhesus Macaque
Purity	>95%
Purification	Affinity Purification
Uniprot ID	A0A2K5UCD9
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

蛋白溶解后浓度偏低，如何调整？

低速离心：12,000 rpm, 5分钟，去除不溶物。缓冲液置换：使用超滤离心管（如10 kDa截留分子量）浓缩。
如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。

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