Human CD223 Protein, His Tag_天津卡梅德科技发展有限公司

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Human CD223 Protein, His Tag

Human CD223 Protein, His Tag

产品编号

KMP2427

别名

淋巴细胞活化基因3, Lymphocyte activation gene 3 protein, LAG3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2427
Alias	淋巴细胞活化基因3, Lymphocyte activation gene 3 protein, LAG3
Size	50ug, 100ug, 200ug
Product Description	The Human CD233 Protein(KMP2427) is produced in HEK293 Cells and the target gene encoding Leu23-Leu450 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD223
Product Introduction	CD223（LAG-3）：免疫调节受体，以跨膜形式表达于免疫细胞，参与T细胞功能调控。
Molecular Weight	47.02 kDa
Expression System	HEK293 Cells
Species	Human
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, 2mM EDTA, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin(Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

蛋白溶解后浓度偏低，如何调整？

低速离心：12,000 rpm, 5分钟，去除不溶物。缓冲液置换：使用超滤离心管（如10 kDa截留分子量）浓缩。
如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。

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