Human CD357 Protein, Fc Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Human CD357 Protein, Fc Tag

Human CD357 Protein, Fc Tag

产品编号

KMP2424

别名

肿瘤坏死因子受体超家族成员 18, Tumor necrosis factor receptor superfamily member 18, CD357

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Catalog Number	KMP2424
Alias	肿瘤坏死因子受体超家族成员 18, Tumor necrosis factor receptor superfamily member 18, CD357
Size	50ug, 100ug, 200ug
Product Description	The Human CD357 Protein(KMP2424) is produced in HEK293 Cells and the target gene encoding Gln26-Gln161 is expressed with a Fc tag at the C-terminus.
Molecular Name	CD357
Product Introduction	CD357（TNFRSF18）：一种TNF受体超家族跨膜蛋白，主要表达于T细胞表面，通过配体结合参与免疫细胞活化和功能调控。
Molecular Weight	14.53 kDa
Expression System	HEK293 Cells
Species	Human
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	Q9Y5U5
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何避免重组蛋白降解？

可在纯化过程中加入蛋白酶抑制剂、低温操作，优化储存条件（如分装冻存于-80°C），并避免反复冻融。某些情况下，可选用蛋白酶缺陷型宿主菌减少降解风险。
如何检测重组蛋白的表达和纯度？

常用SDS-PAGE、Western Blot检测表达，BCA/Bradford法测浓度，HPLC或质谱分析纯度，生物活性实验（如ELISA、酶活检测）验证功能。

推荐产品

400-621-6806
18630936064（微信同号）
周一至周五 8:30-18:00
0