Human CD252 Protein, His Tag_天津卡梅德科技发展有限公司

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Human CD252 Protein, His Tag

Human CD252 Protein, His Tag

产品编号

KMP2414

别名

肿瘤坏死因子受体超家族成员 4, Tumor necrosis factor ligand superfamily member 4, OX40L

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Catalog Number	KMP2414
Alias	肿瘤坏死因子受体超家族成员 4, Tumor necrosis factor ligand superfamily member 4, OX40L
Size	50ug, 100ug, 200ug
Product Description	The Human CD252 Protein(KMP2414) is produced in HEK293 Cells and the target gene encoding Gln51-Leu183 is expressed with a 6His tag at the N-terminus.
Molecular Name	CD252
Product Introduction	CD252（OX40L）：TNF超家族成员，通过跨膜形式作为CD134（OX40）的配体参与T细胞活化。
Molecular Weight	16.25 kDa
Expression System	HEK293 Cells
Species	Human
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	Q9UPC5
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	20mM PB, 150mM NaCl, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells, T cells, dendritic cells and endothelial cells. OX40L binds to OX40(CD134), a member of the TNF receptor superfamily that is expressed predominantly on activated CD4+ T cells. OX40-OX40L co-stimulates signal to promote the survival and proliferation of activated CD4+ T cells and prolong the immune response. It involved in T-cell proliferation and cytokine production. Additional, it has been found association with systemic lupus erythematosus, no association with occurrence of atherosclerosis.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何避免重组蛋白降解？

可在纯化过程中加入蛋白酶抑制剂、低温操作，优化储存条件（如分装冻存于-80°C），并避免反复冻融。某些情况下，可选用蛋白酶缺陷型宿主菌减少降解风险。
如何检测重组蛋白的表达和纯度？

常用SDS-PAGE、Western Blot检测表达，BCA/Bradford法测浓度，HPLC或质谱分析纯度，生物活性实验（如ELISA、酶活检测）验证功能。

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