Mouse CD160 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse CD160 Protein, His Tag

Mouse CD160 Protein, His Tag

产品编号

KMP2401

别名

自然杀伤细胞受体BY55, CD160 antigen, CD160

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2401
Alias	自然杀伤细胞受体BY55, CD160 antigen, CD160
Size	50ug, 100ug, 200ug
Product Description	The Mouse CD160 Protein(KMP2401) is produced in HEK293 Cells and the target gene encoding Gly28-Ser160 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD160
Product Introduction	CD160：免疫球蛋白超家族（IgSF）糖蛋白，以GPI锚定或跨膜形式表达于NK细胞毒性亚群，通过特异性配体结合参与免疫信号传导。
Molecular Weight	15.82 kDa
Expression System	HEK293 Cells
Species	Mouse
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	O88875
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	CD160 antigen is a cell membrane protein which contains one Ig-likeV-type(immunoglobulin-like) domain. CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim) CD16(+) peripheral blood NK subset. CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 is expressed in spleen, peripheral blood, and smal lintestine. Expression of CD160 is restricted to functional NK and T cytotoxic lymphocytes. CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Activated NK lymphocytes release a soluble form of CD160 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何避免重组蛋白降解？

可在纯化过程中加入蛋白酶抑制剂、低温操作，优化储存条件（如分装冻存于-80°C），并避免反复冻融。某些情况下，可选用蛋白酶缺陷型宿主菌减少降解风险。
如何检测重组蛋白的表达和纯度？

常用SDS-PAGE、Western Blot检测表达，BCA/Bradford法测浓度，HPLC或质谱分析纯度，生物活性实验（如ELISA、酶活检测）验证功能。

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