Cynomolgus CD223 Protein, Fc Tag_天津卡梅德科技发展有限公司

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Cynomolgus CD223 Protein, Fc Tag

Cynomolgus CD223 Protein, Fc Tag

产品编号

KMP2400

别名

淋巴细胞活化基因3, Lymphocyte activation gene 3 protein, LAG3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2400
Alias	淋巴细胞活化基因3, Lymphocyte activation gene 3 protein, LAG3
Size	50ug, 100ug, 200ug
Product Description	The Cynomolgus CD223 Protein(KMP2400) is produced in HEK293 Cells and the target gene encoding Ala18-His449(Pro74) is expressed with a Fc tag at the C-terminus.
Molecular Name	CD223
Product Introduction	CD223（LAG-3）：免疫调节受体，以跨膜形式表达于免疫细胞，参与T细胞功能调控。
Molecular Weight	47.52 kDa
Expression System	HEK293 Cells
Species	Cynomolgus
Purity	>90%
Purification	Affinity Purification
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	50mM Tris, 100mM Glycine, pH7.5
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin(Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何避免重组蛋白降解？

可在纯化过程中加入蛋白酶抑制剂、低温操作，优化储存条件（如分装冻存于-80°C），并避免反复冻融。某些情况下，可选用蛋白酶缺陷型宿主菌减少降解风险。
如何检测重组蛋白的表达和纯度？

常用SDS-PAGE、Western Blot检测表达，BCA/Bradford法测浓度，HPLC或质谱分析纯度，生物活性实验（如ELISA、酶活检测）验证功能。

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