Cynomolgus HAVCR2 Protein, His Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Cynomolgus HAVCR2 Protein, His Tag

Cynomolgus HAVCR2 Protein, His Tag

产品编号

KMP2399

别名

甲型肝炎病毒细胞受体 2, Hepatitis A virus cellular receptor 2, HAVCR2

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Catalog Number	KMP2399
Alias	甲型肝炎病毒细胞受体 2, Hepatitis A virus cellular receptor 2, HAVCR2
Size	50ug, 100ug, 200ug
Product Description	The Cynomolgus HAVCR2 Protein(KMP2399) is produced in HEK293 Cells and the target gene encoding Ser22-Arg201 is expressed with a 8His tag at the N-terminus.
Molecular Name	HAVCR2
Product Introduction	HAVCR2（TIM-3）：免疫调节跨膜蛋白，在耗竭T细胞表面高表达，参与免疫应答的负调控。
Molecular Weight	20.46 kDa
Expression System	HEK293 Cells
Species	Cynomolgus
Purity	>95%
Purification	Affinity Purification
Uniprot ID	A0A2K5U3G7
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid(aa)extracellular domain(ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells(macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells(Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

蛋白溶解后浓度偏低，如何调整？:低速离心：12,000 rpm, 5分钟，去除不溶物。缓冲液置换：使用超滤离心管（如10 kDa截留分子量）浓缩。
如何提高重组蛋白的可溶性表达？:可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。

推荐产品

400-621-6806
18630936064（微信同号）
周一至周五 8:30-18:00
0