Human CD275 Protein, His Tag_天津卡梅德科技发展有限公司

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Human CD275 Protein, His Tag

Human CD275 Protein, His Tag

产品编号

KMP2394

别名

诱导性T细胞促刺激配体, B7 homolog 2, B7-H2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2394
Alias	诱导性T细胞促刺激配体, B7 homolog 2, B7-H2
Size	50ug, 100ug, 200ug
Product Description	The Human CD275 Protein(KMP2394) is produced in HEK293 Cells and the target gene encoding Asp19-Ser258 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD275
Product Introduction	CD275（ICOSL）：免疫球蛋白超家族（IgSF）成员，以跨膜形式作为ICOS的配体参与T细胞活化。
Molecular Weight	27.51 kDa
Expression System	HEK293 Cells
Species	Human
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	O75144
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	20mM PB, 150mM NaCl, 1mM EDTA, pH7.2
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Inducible Co-Stimulator Ligand(ICOSLG) belongs to the immunoglobulin superfamily. ICOSLG contains Ig-like C2-type(immunoglobulin-like) domain and 1 Ig-like V-type(immunoglobulin-like) domain. ICOSLG acts as a costimulatory signal for T-cell proliferation and cytokine secretion, it also induces B-cell proliferation and differentiation into plasma cells. It could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. ICOSLG is widely expressed lymph nodes, leukocytes and spleen, detected on activated monocytes and dendritic cells.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

蛋白溶解后浓度偏低，如何调整？

低速离心：12,000 rpm, 5分钟，去除不溶物。缓冲液置换：使用超滤离心管（如10 kDa截留分子量）浓缩。
如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。

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