Cynomolgus CD134 Protein, His Tag_天津卡梅德科技发展有限公司

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Cynomolgus CD134 Protein, His Tag

Cynomolgus CD134 Protein, His Tag

产品编号

KMP2387

别名

肿瘤坏死因子受体超家族成员4, Tumor necrosis factor receptor superfamily member 4, CD134

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Catalog Number	KMP2387
Alias	肿瘤坏死因子受体超家族成员4, Tumor necrosis factor receptor superfamily member 4, CD134
Size	50ug, 100ug, 200ug
Product Description	The Cynomolgus CD134 Protein(KMP2387) is produced in HEK293 Cells and the target gene encoding Lys28-Ala214 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD134
Product Introduction	CD134（OX40）：TNF受体超家族成员，主要表达于活化T细胞，通过配体结合增强T细胞活化和增殖。
Molecular Weight	20.81 kDa
Expression System	HEK293 Cells
Species	Cynomolgus
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	A0A2K5TJH8
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand(OX40L) will occur when activated T cells bind to professional antigen-presenting cells(APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。
重组蛋白纯化常用的方法有哪些？

常用的纯化方法包括亲和层析（如His-Tag、GST-Tag）、离子交换层析、疏水相互作用层析（HIC）和凝胶过滤层析。具体方法取决于蛋白特性和标签类型。

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