Human CD48 Protein, Fc Tag, His Tag_天津卡梅德科技发展有限公司

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Human CD48 Protein, Fc Tag, His Tag

Human CD48 Protein, Fc Tag, His Tag

产品编号

KMP2386

别名

信号传导淋巴细胞活化分子2, SLAM Family Member 2, CD48

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2386
Alias	信号传导淋巴细胞活化分子2, SLAM Family Member 2, CD48
Size	50ug, 100ug, 200ug
Product Description	The Human CD48 Protein(KMP2386) is produced in HEK293 Cells and the target gene encoding Gln27-Ser220 is expressed with a Fc, 6His tag at the C-terminus.
Molecular Name	CD48
Product Introduction	CD48：糖基磷脂酰肌醇（GPI）锚定蛋白，作为CD2的配体在淋巴细胞表面表达，参与免疫细胞间的黏附作用。
Molecular Weight	22 kDa
Expression System	HEK293 Cells
Species	Human
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	P09326
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	CD48 antigen, also known as B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, TCT.1, CD48, BCM1,and BLAST1, CD48 contains one Ig-like C2-type domain and one Ig-like V-type domain, but does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. CD48 may facilitate interaction between activated lymphocytes and be involved in regulating T-cell activation. CD48 plays a vital role as an environmental sensor for regulating progenitor cell numbers and inhibiting tumor development. It is suggested that the anti-CD48 mAb has the potential to become an effective therapeutic mAb against multiple myeloma.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。
重组蛋白纯化常用的方法有哪些？

常用的纯化方法包括亲和层析（如His-Tag、GST-Tag）、离子交换层析、疏水相互作用层析（HIC）和凝胶过滤层析。具体方法取决于蛋白特性和标签类型。

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