Mouse CD137 Protein, Fc Tag_天津卡梅德科技发展有限公司

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Mouse CD137 Protein, Fc Tag

Mouse CD137 Protein, Fc Tag

产品编号

KMP2373

别名

肿瘤坏死因子超家族受体9, CD137, ILA

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2373
Alias	肿瘤坏死因子超家族受体9, CD137, ILA
Size	50ug, 100ug, 200ug
Product Description	The Mouse CD137 Protein(KMP2373) is produced in HEK293 Cells and the target gene encoding Val24-Leu187 is expressed with a Fc tag at the C-terminus.
Molecular Name	CD137
Product Introduction	CD137（4-1BB）：重要的共刺激分子，以跨膜形式表达于免疫细胞表面，参与增强免疫应答和细胞存活。
Molecular Weight	17.4 kDa
Expression System	HEK293 Cells
Species	Mouse
Purity	>95%
Purification	Affinity Purification
Uniprot ID	P20334
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	20mM PB, 150mM NaCl, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor(TNF) receptor family. It can be induced by lymphocyte activation(ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何避免重组蛋白降解？

可在纯化过程中加入蛋白酶抑制剂、低温操作，优化储存条件（如分装冻存于-80°C），并避免反复冻融。某些情况下，可选用蛋白酶缺陷型宿主菌减少降解风险。
如何检测重组蛋白的表达和纯度？

常用SDS-PAGE、Western Blot检测表达，BCA/Bradford法测浓度，HPLC或质谱分析纯度，生物活性实验（如ELISA、酶活检测）验证功能。

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