Mouse CD274 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse CD274 Protein, His Tag

Mouse CD274 Protein, His Tag

产品编号

KMP2371

别名

程序性死亡蛋白配体-1, programmed cell death 1 ligand 1, CD274

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	程序性死亡蛋白配体-1, programmed cell death 1 ligand 1, CD274
Catalog Number	KMP2371
Product Description	The Mouse CD274 Protein(KMP2371) is produced in HEK293 Cells and the target gene encoding Phe19-Thr238 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD274
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM PB, 150mM NaCl, pH7.4
Background	Mouse Programmed cell death 1 ligand 1(Cd274,PD-L1), is a member of the growing B7 family of immune proteins.It involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.B7-H1 has been identified as one of two ligands for programmed death1(PD1), a member of the CD28 family of immunoreceptors. B7-H1 is constitutively expressed in several organs such as heart, skeletal muscle B7-H1 expression is upregulated in a small fraction of activated T and B cells and a much larger fraction of activated monocytes. The costimulatory function of B7-H1 is critical for enhancing maturation and differentiation of T-cells in lymphoid organs.B7-H1 expression is also induced in dendritic cells and keratinocytes after IFN gamma stimulation. Interaction of B7-H1 with PD1 results in inhibition of TCR-mediated proliferation and cytokine production. The B7-H1:PD1 pathway is involved in the negative regulation of some immune responses and may play an important role in the regulation of peripheral tolerance.
SDS-PAGE
Predicted Molecular Weight	25.59 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q3U472

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