Human CD223 Protein, His Tag_天津卡梅德科技发展有限公司

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Human CD223 Protein, His Tag

Human CD223 Protein, His Tag

产品编号

KMP2363

别名

淋巴细胞激活基因-3, Lymphocyte activation gene 3 protein, LAG3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2363
Alias	淋巴细胞激活基因-3, Lymphocyte activation gene 3 protein, LAG3
Size	50ug, 100ug, 200ug
Product Description	The Human CD223 Protein(KMP2363) is produced in HEK293 Cells and the target gene encoding Leu23-Gly434 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD223
Product Introduction	CD223（LAG-3）：免疫调节受体，以跨膜形式表达于免疫细胞，参与T细胞功能调控。
Molecular Weight	45.47 kDa
Expression System	HEK293 Cells
Species	Human
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	A2QHE5
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin(Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何储存293F细胞中表达的蛋白？

蛋白可以在-80°C下储存以便长期保存。应分装并避免冻融循环，以保持蛋白的稳定性。
如何提高293F细胞中的蛋白表达效率？

可以通过优化质粒设计、使用高效转染试剂、优化细胞培养条件以及使用蛋白折叠伴侣或密码子优化来提高蛋白表达效率。

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