Cynomolgus CD137 Protein, His Tag_天津卡梅德科技发展有限公司

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Cynomolgus CD137 Protein, His Tag

Cynomolgus CD137 Protein, His Tag

产品编号

KMP2345

别名

肿瘤坏死因子超家族受体9, CD137, ILA

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2345
Alias	肿瘤坏死因子超家族受体9, CD137, ILA
Size	50ug, 100ug, 200ug
Product Description	The Cynomolgus CD137 Protein(KMP2345) is produced in HEK293 Cells and the target gene encoding Leu24-Gln186 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD137
Product Introduction	CD137（4-1BB）：重要的共刺激分子，以跨膜形式表达于免疫细胞表面，参与增强免疫应答和细胞存活。
Molecular Weight	18.11 kDa
Expression System	HEK293 Cells
Species	Cynomolgus
Purity	>90%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	A9YYE7
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necrosis factor receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. CD137 is expressed by mesenchymal cells, including endothelial cells, chondrocytes, and cells of the central nervous system. CD137 is also broadly expressed by cells of the human immune system, is broadly expressed by cells of the human immune system, including activated CD8+ and CD4+ T cells, activated natural killer(NK) cells, follicular dendritic cells(FDCs) and monocytes. CD137 has diverse roles in the immune response, the one key function is to promote the survival of both T cells and dendritic cells by binding the cognate ligand CD137L(4-1BBL).
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何储存293F细胞中表达的蛋白？

蛋白可以在-80°C下储存以便长期保存。应分装并避免冻融循环，以保持蛋白的稳定性。
如何提高293F细胞中的蛋白表达效率？

可以通过优化质粒设计、使用高效转染试剂、优化细胞培养条件以及使用蛋白折叠伴侣或密码子优化来提高蛋白表达效率。

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