Mouse HAVCR2 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse HAVCR2 Protein, His Tag

Mouse HAVCR2 Protein, His Tag

产品编号

KMP2340

别名

甲型肝炎病毒细胞受体 2, Hepatitis A virus cellular receptor 2, HAVCR2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2340
Alias	甲型肝炎病毒细胞受体 2, Hepatitis A virus cellular receptor 2, HAVCR2
Size	50ug, 100ug, 200ug
Product Description	The Mouse HAVCR2 Protein(KMP2340) is produced in HEK293 Cells and the target gene encoding Arg20-Ala193 is expressed with a 6His tag at the C-terminus.
Molecular Name	HAVCR2
Product Introduction	HAVCR2（TIM-3）：免疫调节跨膜蛋白，在耗竭T细胞表面高表达，参与免疫应答的负调控。
Molecular Weight	19.95 kDa
Expression System	HEK293 Cells
Species	Mouse
Purity	>95%
Purification	Affinity Purification
Uniprot ID	Q3KP82
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	T cell immunoglobulin and mucin domain-3(TIM3), also called hepatitis A virus cellular receptor 2(HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1(PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

蛋白溶解后浓度偏低，如何调整？:低速离心：12,000 rpm, 5分钟，去除不溶物。缓冲液置换：使用超滤离心管（如10 kDa截留分子量）浓缩。
如何提高重组蛋白的可溶性表达？:可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。

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