Mouse CD86 Protein, Fc Tag_天津卡梅德科技发展有限公司

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Mouse CD86 Protein, Fc Tag

Mouse CD86 Protein, Fc Tag

产品编号

KMP2337

别名

T 淋巴细胞活化抗原 CD86, T-lymphocyte activation antigen CD86, CD86

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2337
Alias	T 淋巴细胞活化抗原 CD86, T-lymphocyte activation antigen CD86, CD86
Size	50ug, 100ug, 200ug
Product Description	The Mouse CD86 Protein(KMP2337) is produced in HEK293 Cells and the target gene encoding Val26-Glu245 is expressed with a Fc tag at the C-terminus.
Molecular Name	CD86
Product Introduction	CD86（B7-2）：免疫球蛋白超家族跨膜蛋白，与CD80协同作用，提供T细胞活化的共刺激信号。
Molecular Weight	25.05 kDa
Expression System	HEK293 Cells
Species	Mouse
Purity	>95%
Purification	Affinity Purification
Uniprot ID	Q91YV7
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	T-lymphocyte activation antigen CD86(B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play important roles in immune activation and the maintenance of immune tolerance. Mouse CD86 shares 59% and 81% aa sequence identity with human and rat CD86, respectively. It contains 1 Ig-like C2-type domainand 1 Ig-like V-type domain. It is highly expressed on activated antigen presenting cells. CD86 involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何储存293F细胞中表达的蛋白？

蛋白可以在-80°C下储存以便长期保存。应分装并避免冻融循环，以保持蛋白的稳定性。
如何提高293F细胞中的蛋白表达效率？

可以通过优化质粒设计、使用高效转染试剂、优化细胞培养条件以及使用蛋白折叠伴侣或密码子优化来提高蛋白表达效率。

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