Mouse CD80 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse CD80 Protein, His Tag

Mouse CD80 Protein, His Tag

产品编号

KMP2333

别名

T淋巴细胞活化抗原CD80, T-lymphocyte activation antigen CD80, Activation B7-1 antigen

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Catalog Number	KMP2333
Alias	T淋巴细胞活化抗原CD80, T-lymphocyte activation antigen CD80, Activation B7-1 antigen
Size	50ug, 100ug, 200ug
Product Description	The Mouse CD80 Protein(KMP2333) is produced in HEK293 Cells and the target gene encoding Val38-Asn246 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD80
Product Introduction	CD80（B7-1）：免疫球蛋白超家族跨膜蛋白，作为CD28/CTLA-4的配体，在抗原呈递细胞表面表达。
Molecular Weight	24.63 kDa
Expression System	HEK293 Cells
Species	Mouse
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	Q00609
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. Mouse CD80 consists of an extracellular domain(ECD) with twoimmunoglobulin-like domains, transmembrane segment, and cytoplasmic domain. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何储存293F细胞中表达的蛋白？

蛋白可以在-80°C下储存以便长期保存。应分装并避免冻融循环，以保持蛋白的稳定性。
如何提高293F细胞中的蛋白表达效率？

可以通过优化质粒设计、使用高效转染试剂、优化细胞培养条件以及使用蛋白折叠伴侣或密码子优化来提高蛋白表达效率。

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