Mouse VTCN1 Protein, Fc Tag_天津卡梅德科技发展有限公司

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Mouse VTCN1 Protein, Fc Tag

Mouse VTCN1 Protein, Fc Tag

产品编号

KMP2324

别名

含 V 组结构域的 T 细胞激活抑制剂 1, T cell costimulatory molecule B7x, VTCN1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2324
Alias	含 V 组结构域的 T 细胞激活抑制剂 1, T cell costimulatory molecule B7x, VTCN1
Size	50ug, 100ug, 200ug
Product Description	The Mouse VTCN1 Protein(KMP2324) is produced in HEK293 Cells and the target gene encoding Leu25-Ser256 is expressed with a Fc tag at the C-terminus.
Molecular Name	VTCN1
Product Introduction	VTCN1（B7-H4）：免疫球蛋白超家族跨膜蛋白，在抗原呈递细胞表面表达，参与T细胞活化的负调控。
Molecular Weight	25.56 kDa
Expression System	HEK293 Cells
Species	Mouse
Purity	>95%
Purification	Affinity Purification
Uniprot ID	Q7TSP5
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Mouse V-set domain-containing T-cell activation inhibitor 1/VTCN1/B7-H4 is glycosylated member of the B7 family of immune co-stimulatory proteins. B7-H4 consists of extracellular domain(ECD) with one Ig-like V-set domain and one Ig-like C2-set domain. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

蛋白溶解后浓度偏低，如何调整？

低速离心：12,000 rpm, 5分钟，去除不溶物。缓冲液置换：使用超滤离心管（如10 kDa截留分子量）浓缩。
如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。

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