Mouse Gi24 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse Gi24 Protein, His Tag

Mouse Gi24 Protein, His Tag

产品编号

KMP2323

别名

V 集免疫调节受体, Platelet receptor Gi24, Gi24

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	V 集免疫调节受体, Platelet receptor Gi24, Gi24
Catalog Number	KMP2323
Product Description	The Mouse Gi24 Protein(KMP2323) is produced in HEK293 Cells and the target gene encoding Phe33-Ala191 is expressed with a 6His tag at the C-terminus.
Molecular Name	Gi24
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Mouse Platelet receptor Gi24(VISTA) is a transmembrane glycoprotein with homology to B7like immune costimulatory molecules. Mature mouse Gi24 contains a 159 amino acid(aa) extracellular domain(ECD) with one V-type Ig-like domain, a 21 aa transmembrane segment, and a 97 aa cytoplasmic domain. VISTA promotes both MT1-MMP expression and the MT1-MMP mediated activation of MMP-2. It supports the differentiation of embryonic stem cells(ESC) and enhances BMP-4 induced signaling in ESC, but it is also down-regulated following BMP-4 exposure. It binds to BMP-4 directly and also associates with the type I BMP receptor Activin RIB/ALK-4. It is expressed on the surface of na-ve CD4+ T cells and regulatory T cells. It is up-regulated in vivo on activated monocytes and dendritic cells. VISTA inhibits CD4+ and CD8+ T cell proliferation and their production of IL-2 and IFN-γ. Its expression on tumor cells attenuates the antitumor immune response and enables more rapid tumor progression.
SDS-PAGE
Predicted Molecular Weight	18.96 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q9D659
References	1.J. Biol. Chem. 285:7776-7783 (2010) 2.J. Exp. Med. 208:577-592 (2011) 3.J. Clin. Invest. 124:1966-1975 (2014) 4.Proc. Natl. Acad. Sci. U.S.A. 111:14846-14851 (2014)
Function	Immunoregulatory receptor which inhibits the T-cell response (PubMed:21383057, PubMed:24743150, PubMed:25267631). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (PubMed:20042595). May stimulate MMP14-mediated MMP2 activation (By similarity).

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