Cynomolgus HAVCR2 Protein, Fc Tag_天津卡梅德科技发展有限公司

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Cynomolgus HAVCR2 Protein, Fc Tag

Cynomolgus HAVCR2 Protein, Fc Tag

产品编号

KMP2310

别名

甲型肝炎病毒细胞受体 2, Hepatitis A virus cellular receptor 2, HAVCR2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2310
Alias	甲型肝炎病毒细胞受体 2, Hepatitis A virus cellular receptor 2, HAVCR2
Size	50ug, 100ug, 200ug
Product Description	The Cynomolgus HAVCR2 Protein(KMP2310) is produced in HEK293 Cells and the target gene encoding Ser22-Arg201 is expressed with a Fc tag at the C-terminus.
Molecular Name	HAVCR2
Product Introduction	HAVCR2（TIM-3）：免疫调节跨膜蛋白，在耗竭T细胞表面高表达，参与免疫应答的负调控。
Molecular Weight	19.8 kDa
Expression System	HEK293 Cells
Species	Cynomolgus
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	G7P6Q7
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid(aa)extracellular domain(ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells(macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells(Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。
重组蛋白纯化常用的方法有哪些？

常用的纯化方法包括亲和层析（如His-Tag、GST-Tag）、离子交换层析、疏水相互作用层析（HIC）和凝胶过滤层析。具体方法取决于蛋白特性和标签类型。

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