Rhesus Macaque CD86 Protein, His Tag_天津卡梅德科技发展有限公司

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Rhesus Macaque CD86 Protein, His Tag

Rhesus Macaque CD86 Protein, His Tag

产品编号

KMP2298

别名

T 淋巴细胞活化抗原 CD86, T-lymphocyte activation antigen CD86, CD86

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Catalog Number	KMP2298
Alias	T 淋巴细胞活化抗原 CD86, T-lymphocyte activation antigen CD86, CD86
Size	50ug, 100ug, 200ug
Product Description	The Rhesus Macaque CD86 Protein(KMP2298) is produced in HEK293 Cells and the target gene encoding Tyr31-Pro247 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD86
Product Introduction	CD86（B7-2）：免疫球蛋白超家族跨膜蛋白，与CD80协同作用，提供T细胞活化的共刺激信号。
Molecular Weight	24.53 kDa
Expression System	HEK293 Cells
Species	Rhesus Macaque
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	H9ZFI8
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	T-lymphocyte activation antigen CD86(B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play important roles in immune activation and the maintenance of immune tolerance. It is highly expressed on activated antigen presenting cells. CD86 involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

蛋白溶解后浓度偏低，如何调整？

低速离心：12,000 rpm, 5分钟，去除不溶物。缓冲液置换：使用超滤离心管（如10 kDa截留分子量）浓缩。
如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。

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